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Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion

The purpose of this study was to determine if the Entonox gas could cause adequate analgesic and sedative effects in patients who need cardioversion. In this randomized not blinded clinical trial, the sedative and analgesic effects of midazolam and fentanyl were compared with Entonox. Eligible patie...

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Detalles Bibliográficos
Autores principales: Masoumi, Kambiz, Forouzan, Arash, Saghari, Sina, Feli, Maryam, Sattari, Ali Reza, Asgari Darian, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630375/
https://www.ncbi.nlm.nih.gov/pubmed/26576298
http://dx.doi.org/10.1155/2015/798478
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author Masoumi, Kambiz
Forouzan, Arash
Saghari, Sina
Feli, Maryam
Sattari, Ali Reza
Asgari Darian, Ali
author_facet Masoumi, Kambiz
Forouzan, Arash
Saghari, Sina
Feli, Maryam
Sattari, Ali Reza
Asgari Darian, Ali
author_sort Masoumi, Kambiz
collection PubMed
description The purpose of this study was to determine if the Entonox gas could cause adequate analgesic and sedative effects in patients who need cardioversion. In this randomized not blinded clinical trial, the sedative and analgesic effects of midazolam and fentanyl were compared with Entonox. Eligible patients who need synchronized cardioversion because of dysrhythmia were randomly divided into two groups. The first group received intravenous midazolam and fentanyl; the second group received Entonox through a blower-dependent mask. Onset and end of sedation, sedation level, and pain score were recorded. There were nonsignificant differences between the two groups (22 patients in each group) regarding age, gender, weight, sedation level, and frequency and level of shock. The pain score recorded in the first group was 5.05 ± 1.32, and 3.9 ± 0.7 in the second group (P = 0.002). Furthermore, sedation duration and time to full recovery consciousness were shorter in the second group (P < 0.001). In the first group, seven patients needed additional doses to induce and maintain sedation. In addition, as a result of apnoea, four patients required airway support. None of them occurred in the second group. Entonox is a suitable medication in rapid cardioversion, as it has minimal side effects and adequate analgesic and sedative effects.
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spelling pubmed-46303752015-11-16 Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion Masoumi, Kambiz Forouzan, Arash Saghari, Sina Feli, Maryam Sattari, Ali Reza Asgari Darian, Ali Crit Care Res Pract Clinical Study The purpose of this study was to determine if the Entonox gas could cause adequate analgesic and sedative effects in patients who need cardioversion. In this randomized not blinded clinical trial, the sedative and analgesic effects of midazolam and fentanyl were compared with Entonox. Eligible patients who need synchronized cardioversion because of dysrhythmia were randomly divided into two groups. The first group received intravenous midazolam and fentanyl; the second group received Entonox through a blower-dependent mask. Onset and end of sedation, sedation level, and pain score were recorded. There were nonsignificant differences between the two groups (22 patients in each group) regarding age, gender, weight, sedation level, and frequency and level of shock. The pain score recorded in the first group was 5.05 ± 1.32, and 3.9 ± 0.7 in the second group (P = 0.002). Furthermore, sedation duration and time to full recovery consciousness were shorter in the second group (P < 0.001). In the first group, seven patients needed additional doses to induce and maintain sedation. In addition, as a result of apnoea, four patients required airway support. None of them occurred in the second group. Entonox is a suitable medication in rapid cardioversion, as it has minimal side effects and adequate analgesic and sedative effects. Hindawi Publishing Corporation 2015 2015-10-20 /pmc/articles/PMC4630375/ /pubmed/26576298 http://dx.doi.org/10.1155/2015/798478 Text en Copyright © 2015 Kambiz Masoumi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Masoumi, Kambiz
Forouzan, Arash
Saghari, Sina
Feli, Maryam
Sattari, Ali Reza
Asgari Darian, Ali
Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion
title Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion
title_full Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion
title_fullStr Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion
title_full_unstemmed Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion
title_short Sedative and Analgesic Effects of Entonox Gas Compared with Midazolam and Fentanyl in Synchronized Cardioversion
title_sort sedative and analgesic effects of entonox gas compared with midazolam and fentanyl in synchronized cardioversion
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630375/
https://www.ncbi.nlm.nih.gov/pubmed/26576298
http://dx.doi.org/10.1155/2015/798478
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