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Gender Differences in Childhood Lyme Neuroborreliosis

Background. Many neurological diseases show differences between genders. We studied gender differences in childhood Lyme neuroborreliosis (LNB) in an endemic area of Lyme borreliosis in Norway. Methods. In a population based study, all children (<14 years of age) with symptoms suspicious of LNB,...

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Autores principales: Tveitnes, Dag, Øymar, Knut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630376/
https://www.ncbi.nlm.nih.gov/pubmed/26576072
http://dx.doi.org/10.1155/2015/790762
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author Tveitnes, Dag
Øymar, Knut
author_facet Tveitnes, Dag
Øymar, Knut
author_sort Tveitnes, Dag
collection PubMed
description Background. Many neurological diseases show differences between genders. We studied gender differences in childhood Lyme neuroborreliosis (LNB) in an endemic area of Lyme borreliosis in Norway. Methods. In a population based study, all children (<14 years of age) with symptoms suspicious of LNB, including all children with acute facial nerve palsy, were evaluated for LNB by medical history, clinical examination, blood tests, and lumbar puncture. LNB was diagnosed according to international criteria. Results. 142 children were diagnosed with LNB during 2001–2009. Facial nerve palsy was more common in girls (86%) than in boys (62%) (p < 0.001), but headache and/or neck stiffness as the only symptom was more common in boys (30%) than in girls (10%) (p = 0.003). The girls were younger than boys and had a shorter duration of symptoms, but boys had a higher level of pleocytosis than girls. In a multivariate analysis, both gender and having headache and neck stiffness were associated with a higher level of pleocytosis. Conclusion. Girls and boys have different clinical presentations of LNB, and boys have a higher level of inflammation than girls independent of the clinical presentation.
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spelling pubmed-46303762015-11-16 Gender Differences in Childhood Lyme Neuroborreliosis Tveitnes, Dag Øymar, Knut Behav Neurol Research Article Background. Many neurological diseases show differences between genders. We studied gender differences in childhood Lyme neuroborreliosis (LNB) in an endemic area of Lyme borreliosis in Norway. Methods. In a population based study, all children (<14 years of age) with symptoms suspicious of LNB, including all children with acute facial nerve palsy, were evaluated for LNB by medical history, clinical examination, blood tests, and lumbar puncture. LNB was diagnosed according to international criteria. Results. 142 children were diagnosed with LNB during 2001–2009. Facial nerve palsy was more common in girls (86%) than in boys (62%) (p < 0.001), but headache and/or neck stiffness as the only symptom was more common in boys (30%) than in girls (10%) (p = 0.003). The girls were younger than boys and had a shorter duration of symptoms, but boys had a higher level of pleocytosis than girls. In a multivariate analysis, both gender and having headache and neck stiffness were associated with a higher level of pleocytosis. Conclusion. Girls and boys have different clinical presentations of LNB, and boys have a higher level of inflammation than girls independent of the clinical presentation. Hindawi Publishing Corporation 2015 2015-10-20 /pmc/articles/PMC4630376/ /pubmed/26576072 http://dx.doi.org/10.1155/2015/790762 Text en Copyright © 2015 D. Tveitnes and K. Øymar. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tveitnes, Dag
Øymar, Knut
Gender Differences in Childhood Lyme Neuroborreliosis
title Gender Differences in Childhood Lyme Neuroborreliosis
title_full Gender Differences in Childhood Lyme Neuroborreliosis
title_fullStr Gender Differences in Childhood Lyme Neuroborreliosis
title_full_unstemmed Gender Differences in Childhood Lyme Neuroborreliosis
title_short Gender Differences in Childhood Lyme Neuroborreliosis
title_sort gender differences in childhood lyme neuroborreliosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630376/
https://www.ncbi.nlm.nih.gov/pubmed/26576072
http://dx.doi.org/10.1155/2015/790762
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