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Chronic Stress Facilitates the Development of Deep Venous Thrombosis
The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT). Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630420/ https://www.ncbi.nlm.nih.gov/pubmed/26576222 http://dx.doi.org/10.1155/2015/384535 |
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author | Dong, Tao Cheng, Yu-Wen Yang, Fei Sun, Pei-Wen Zhu, Chen-Jie Zhu, Li Zhang, Guo-Xing |
author_facet | Dong, Tao Cheng, Yu-Wen Yang, Fei Sun, Pei-Wen Zhu, Chen-Jie Zhu, Li Zhang, Guo-Xing |
author_sort | Dong, Tao |
collection | PubMed |
description | The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT). Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension. In addition, the close relationship between oxidative stress and cardiovascular diseases has been well documented. The present study is designed to explore the mechanism by which the renal sympathetic nerve system and the oxidative stress affect the blood coagulation system in the development of DVT. Chronic foot shock model in rats was applied to mimic a state of physiological stress similar to humans. Our results showed that chronic foot shock procedure could promote DVT which may be through the activation of platelets aggregation. The aggravation of DVT and activation of platelets were alleviated by renal sympathetic denervation or antioxidant (Tempol) treatment. Concurrently, the denervation treatment could also reduce the levels of circulating oxidation factors in rats. These results demonstrate that both the renal sympathetic nerve system and the oxidative stress contribute to the development of DVT in response to chronic stress, which may provide novel strategy for treatment of clinic DVT patients. |
format | Online Article Text |
id | pubmed-4630420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46304202015-11-16 Chronic Stress Facilitates the Development of Deep Venous Thrombosis Dong, Tao Cheng, Yu-Wen Yang, Fei Sun, Pei-Wen Zhu, Chen-Jie Zhu, Li Zhang, Guo-Xing Oxid Med Cell Longev Research Article The increasing pressure of modern social life intensifies the impact of stress on the development of cardiovascular diseases, which include deep venous thrombosis (DVT). Renal sympathetic denervation has been applied as one of the clinical approaches for the treatment of drug-resistant hypertension. In addition, the close relationship between oxidative stress and cardiovascular diseases has been well documented. The present study is designed to explore the mechanism by which the renal sympathetic nerve system and the oxidative stress affect the blood coagulation system in the development of DVT. Chronic foot shock model in rats was applied to mimic a state of physiological stress similar to humans. Our results showed that chronic foot shock procedure could promote DVT which may be through the activation of platelets aggregation. The aggravation of DVT and activation of platelets were alleviated by renal sympathetic denervation or antioxidant (Tempol) treatment. Concurrently, the denervation treatment could also reduce the levels of circulating oxidation factors in rats. These results demonstrate that both the renal sympathetic nerve system and the oxidative stress contribute to the development of DVT in response to chronic stress, which may provide novel strategy for treatment of clinic DVT patients. Hindawi Publishing Corporation 2015 2015-10-20 /pmc/articles/PMC4630420/ /pubmed/26576222 http://dx.doi.org/10.1155/2015/384535 Text en Copyright © 2015 Tao Dong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dong, Tao Cheng, Yu-Wen Yang, Fei Sun, Pei-Wen Zhu, Chen-Jie Zhu, Li Zhang, Guo-Xing Chronic Stress Facilitates the Development of Deep Venous Thrombosis |
title | Chronic Stress Facilitates the Development of Deep Venous Thrombosis |
title_full | Chronic Stress Facilitates the Development of Deep Venous Thrombosis |
title_fullStr | Chronic Stress Facilitates the Development of Deep Venous Thrombosis |
title_full_unstemmed | Chronic Stress Facilitates the Development of Deep Venous Thrombosis |
title_short | Chronic Stress Facilitates the Development of Deep Venous Thrombosis |
title_sort | chronic stress facilitates the development of deep venous thrombosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630420/ https://www.ncbi.nlm.nih.gov/pubmed/26576222 http://dx.doi.org/10.1155/2015/384535 |
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