Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis

Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multi...

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Detalles Bibliográficos
Autores principales: Castelli, Anthony A., Rosenthal, David G., Bender Ignacio, Rachel, Chu, Helen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630451/
https://www.ncbi.nlm.nih.gov/pubmed/26566535
http://dx.doi.org/10.1093/ofid/ofv140
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author Castelli, Anthony A.
Rosenthal, David G.
Bender Ignacio, Rachel
Chu, Helen Y.
author_facet Castelli, Anthony A.
Rosenthal, David G.
Bender Ignacio, Rachel
Chu, Helen Y.
author_sort Castelli, Anthony A.
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy.
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spelling pubmed-46304512015-11-12 Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis Castelli, Anthony A. Rosenthal, David G. Bender Ignacio, Rachel Chu, Helen Y. Open Forum Infect Dis Brief Reports Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy. Oxford University Press 2015-09-19 /pmc/articles/PMC4630451/ /pubmed/26566535 http://dx.doi.org/10.1093/ofid/ofv140 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Castelli, Anthony A.
Rosenthal, David G.
Bender Ignacio, Rachel
Chu, Helen Y.
Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis
title Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis
title_full Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis
title_fullStr Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis
title_full_unstemmed Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis
title_short Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis
title_sort hemophagocytic lymphohistiocytosis secondary to human immunodeficiency virus-associated histoplasmosis
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630451/
https://www.ncbi.nlm.nih.gov/pubmed/26566535
http://dx.doi.org/10.1093/ofid/ofv140
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