Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy

Human immunodeficiency virus (HIV)-1-infected individuals are affected by diseases at rates above those of their HIV-negative peers despite the increased life expectancy of the highly active antiretroviral therapy era. We followed a cohort of approximately 2000 HIV-1-infected patients for 5 years. T...

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Autores principales: Griffin, Daniel O., Metzger, Michael, Poeth, Kaitlin, Deng, Kathy, Dharsee, Arif, Rico, Juan Carlos, McGowan, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630453/
https://www.ncbi.nlm.nih.gov/pubmed/26566539
http://dx.doi.org/10.1093/ofid/ofv147
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author Griffin, Daniel O.
Metzger, Michael
Poeth, Kaitlin
Deng, Kathy
Dharsee, Arif
Rico, Juan Carlos
McGowan, Joseph
author_facet Griffin, Daniel O.
Metzger, Michael
Poeth, Kaitlin
Deng, Kathy
Dharsee, Arif
Rico, Juan Carlos
McGowan, Joseph
author_sort Griffin, Daniel O.
collection PubMed
description Human immunodeficiency virus (HIV)-1-infected individuals are affected by diseases at rates above those of their HIV-negative peers despite the increased life expectancy of the highly active antiretroviral therapy era. We followed a cohort of approximately 2000 HIV-1-infected patients for 5 years. The most frequent cause of death in this HIV-1-infected cohort was malignancy, with 39% of all classified deaths due to cancer. Among the cancer deaths, B-cell lymphomas were the most commonly seen malignancy, representing 34% of all cancer deaths. These lymphomas were very aggressive with a median survival of <2 months from time of diagnosis.
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spelling pubmed-46304532015-11-12 Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy Griffin, Daniel O. Metzger, Michael Poeth, Kaitlin Deng, Kathy Dharsee, Arif Rico, Juan Carlos McGowan, Joseph Open Forum Infect Dis Brief Reports Human immunodeficiency virus (HIV)-1-infected individuals are affected by diseases at rates above those of their HIV-negative peers despite the increased life expectancy of the highly active antiretroviral therapy era. We followed a cohort of approximately 2000 HIV-1-infected patients for 5 years. The most frequent cause of death in this HIV-1-infected cohort was malignancy, with 39% of all classified deaths due to cancer. Among the cancer deaths, B-cell lymphomas were the most commonly seen malignancy, representing 34% of all cancer deaths. These lymphomas were very aggressive with a median survival of <2 months from time of diagnosis. Oxford University Press 2015-09-30 /pmc/articles/PMC4630453/ /pubmed/26566539 http://dx.doi.org/10.1093/ofid/ofv147 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Griffin, Daniel O.
Metzger, Michael
Poeth, Kaitlin
Deng, Kathy
Dharsee, Arif
Rico, Juan Carlos
McGowan, Joseph
Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy
title Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy
title_full Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy
title_fullStr Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy
title_full_unstemmed Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy
title_short Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy
title_sort malignancies, particularly b-cell lymphomas, are a frequent cause of mortality in human immunodeficiency virus-1 patients despite highly active antiretroviral therapy
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630453/
https://www.ncbi.nlm.nih.gov/pubmed/26566539
http://dx.doi.org/10.1093/ofid/ofv147
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