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The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER
DNA polymerase β (pol β) is a key enzyme in DNA base excision repair, and an important factor for maintaining genomic integrity and stability. Esophageal carcinoma (EC) patients who have been identified as carrying the K167I variant of pol β have been shown to have decreased life expectancy. However...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630582/ https://www.ncbi.nlm.nih.gov/pubmed/26527528 http://dx.doi.org/10.1038/srep15986 |