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Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria

Crohn’s disease (CD) is an immune-mediated intestinal illness that significantly compromises health in many developed countries. Although definitive causes remain elusive, the required contribution of microbes in the progression of disease has become an accepted concept. Known CD risk factors, such...

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Detalles Bibliográficos
Autores principales: Oberc, Alexander, Coombes, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630591/
https://www.ncbi.nlm.nih.gov/pubmed/26579131
http://dx.doi.org/10.3389/fimmu.2015.00558
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author Oberc, Alexander
Coombes, Brian K.
author_facet Oberc, Alexander
Coombes, Brian K.
author_sort Oberc, Alexander
collection PubMed
description Crohn’s disease (CD) is an immune-mediated intestinal illness that significantly compromises health in many developed countries. Although definitive causes remain elusive, the required contribution of microbes in the progression of disease has become an accepted concept. Known CD risk factors, such as antibiotic use and acute infectious gastroenteritis, may impact the gut. This concept is now being explored with a view toward understanding the beneficial and unfavorable microbes that may be altered in numbers during such external insults. A comprehensive understanding of the microbial component to CD could be useful clinically as future therapies may focus on preventing risk exposures on susceptible individuals, eliminating harmful microbes, or restoring a protective gut microbiome. Here, we examine how acute infectious gastroenteritis and antibiotic exposure may impact the gut microbiota in the context of inflammation in CD.
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spelling pubmed-46305912015-11-17 Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria Oberc, Alexander Coombes, Brian K. Front Immunol Immunology Crohn’s disease (CD) is an immune-mediated intestinal illness that significantly compromises health in many developed countries. Although definitive causes remain elusive, the required contribution of microbes in the progression of disease has become an accepted concept. Known CD risk factors, such as antibiotic use and acute infectious gastroenteritis, may impact the gut. This concept is now being explored with a view toward understanding the beneficial and unfavorable microbes that may be altered in numbers during such external insults. A comprehensive understanding of the microbial component to CD could be useful clinically as future therapies may focus on preventing risk exposures on susceptible individuals, eliminating harmful microbes, or restoring a protective gut microbiome. Here, we examine how acute infectious gastroenteritis and antibiotic exposure may impact the gut microbiota in the context of inflammation in CD. Frontiers Media S.A. 2015-11-03 /pmc/articles/PMC4630591/ /pubmed/26579131 http://dx.doi.org/10.3389/fimmu.2015.00558 Text en Copyright © 2015 Oberc and Coombes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Oberc, Alexander
Coombes, Brian K.
Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria
title Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria
title_full Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria
title_fullStr Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria
title_full_unstemmed Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria
title_short Convergence of External Crohn’s Disease Risk Factors on Intestinal Bacteria
title_sort convergence of external crohn’s disease risk factors on intestinal bacteria
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630591/
https://www.ncbi.nlm.nih.gov/pubmed/26579131
http://dx.doi.org/10.3389/fimmu.2015.00558
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