Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway

Lipopolysaccharide (LPS) derived from Gram-negative bacteria activates plasma membrane signaling via Toll-like receptor 4 (TLR4) on host cells and triggers innate inflammatory responses, but the underlying mechanisms remain to be fully elucidated. Here we reveal a role for annexin A2 (AnxA2) in host...

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Detalles Bibliográficos
Autores principales: Zhang, Shuang, Yu, Min, Guo, Qiang, Li, Rongpeng, Li, Guobo, Tan, Shirui, Li, Xuefeng, Wei, Yuquan, Wu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630631/
https://www.ncbi.nlm.nih.gov/pubmed/26527544
http://dx.doi.org/10.1038/srep15859

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