7T MRI in natalizumab-associated PML and ongoing MS disease activity: A case study

OBJECTIVE: To assess the ability of ultra-high-field MRI to distinguish early progressive multifocal leukoencephalopathy (PML) from multiple sclerosis (MS) lesions in a rare case of simultaneous presentation of natalizumab–associated PML and ongoing MS activity. METHODS: Advanced neuroimaging includ...

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Detalles Bibliográficos
Autores principales: Sinnecker, Tim, Othman, Jalal, Kühl, Marc, Mekle, Ralf, Selbig, Inga, Niendorf, Thoralf, Kunkel, Annett, Wienecke, Peter, Kern, Peter, Paul, Friedemann, Faiss, Juergen, Wuerfel, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630686/
https://www.ncbi.nlm.nih.gov/pubmed/26568970
http://dx.doi.org/10.1212/NXI.0000000000000171
Descripción
Sumario:OBJECTIVE: To assess the ability of ultra-high-field MRI to distinguish early progressive multifocal leukoencephalopathy (PML) from multiple sclerosis (MS) lesions in a rare case of simultaneous presentation of natalizumab–associated PML and ongoing MS activity. METHODS: Advanced neuroimaging including 1.5T, 3T, and 7T MRI with a spatial resolution of up to 0.08 mm(3) was performed. RESULTS: 7T MRI differentiated between PML-related and MS-related brain damage in vivo. Ring-enhancing MS plaques displayed a central vein, whereas confluent PML lesions were preceded by punctate or milky way–like T2 lesions. CONCLUSIONS: Given the importance of early diagnosis of treatment-associated PML, future systematic studies are warranted to assess the value of highly resolving MRI in differentiating between early PML- and MS-induced brain parenchymal lesions.

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