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Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

BACKGROUND: Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from the brain parenchyma along the paravascular pathway. Ho...

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Detalles Bibliográficos
Autores principales:	Xu, Zhiqiang, Xiao, Na, Chen, Yali, Huang, Huang, Marshall, Charles, Gao, Junying, Cai, Zhiyou, Wu, Ting, Hu, Gang, Xiao, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631089/ https://www.ncbi.nlm.nih.gov/pubmed/26526066 http://dx.doi.org/10.1186/s13024-015-0056-1

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