miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells

miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR-122 via adenoviral vector in non-small-cell lung cancer (NSCLC) cells reduces the number of invasion and migration cells...

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Detalles Bibliográficos
Autores principales: Qin, Haifeng, Sha, Jiping, Jiang, Caixia, Gao, Xuemei, Qu, Lili, Yan, Haiying, Xu, Tianjiao, Jiang, Qiyu, Gao, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631421/
https://www.ncbi.nlm.nih.gov/pubmed/26604787
http://dx.doi.org/10.2147/OTT.S91696
Descripción
Sumario:miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR-122 via adenoviral vector in non-small-cell lung cancer (NSCLC) cells reduces the number of invasion and migration cells. miR-122 attenuates the epithelial–mesenchymal transition process, which mediates cancer cells metastasis in NSCLC cells A549 and H460. The mechanisms data reveals that miR-122 would disrupt the epithelial–mesenchymal transition process by downregulating PI3K/AKT activation via reducing endogenous expression of insulin-like growth factor 1 receptor. These data highlight the detailed roles and potential application of miR-122 in NSCLC cells.

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