miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells

miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR-122 via adenoviral vector in non-small-cell lung cancer (NSCLC) cells reduces the number of invasion and migration cells...

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Autores principales: Qin, Haifeng, Sha, Jiping, Jiang, Caixia, Gao, Xuemei, Qu, Lili, Yan, Haiying, Xu, Tianjiao, Jiang, Qiyu, Gao, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631421/
https://www.ncbi.nlm.nih.gov/pubmed/26604787
http://dx.doi.org/10.2147/OTT.S91696
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author Qin, Haifeng
Sha, Jiping
Jiang, Caixia
Gao, Xuemei
Qu, Lili
Yan, Haiying
Xu, Tianjiao
Jiang, Qiyu
Gao, Hongjun
author_facet Qin, Haifeng
Sha, Jiping
Jiang, Caixia
Gao, Xuemei
Qu, Lili
Yan, Haiying
Xu, Tianjiao
Jiang, Qiyu
Gao, Hongjun
author_sort Qin, Haifeng
collection PubMed
description miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR-122 via adenoviral vector in non-small-cell lung cancer (NSCLC) cells reduces the number of invasion and migration cells. miR-122 attenuates the epithelial–mesenchymal transition process, which mediates cancer cells metastasis in NSCLC cells A549 and H460. The mechanisms data reveals that miR-122 would disrupt the epithelial–mesenchymal transition process by downregulating PI3K/AKT activation via reducing endogenous expression of insulin-like growth factor 1 receptor. These data highlight the detailed roles and potential application of miR-122 in NSCLC cells.
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spelling pubmed-46314212015-11-24 miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells Qin, Haifeng Sha, Jiping Jiang, Caixia Gao, Xuemei Qu, Lili Yan, Haiying Xu, Tianjiao Jiang, Qiyu Gao, Hongjun Onco Targets Ther Original Research miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR-122 via adenoviral vector in non-small-cell lung cancer (NSCLC) cells reduces the number of invasion and migration cells. miR-122 attenuates the epithelial–mesenchymal transition process, which mediates cancer cells metastasis in NSCLC cells A549 and H460. The mechanisms data reveals that miR-122 would disrupt the epithelial–mesenchymal transition process by downregulating PI3K/AKT activation via reducing endogenous expression of insulin-like growth factor 1 receptor. These data highlight the detailed roles and potential application of miR-122 in NSCLC cells. Dove Medical Press 2015-10-29 /pmc/articles/PMC4631421/ /pubmed/26604787 http://dx.doi.org/10.2147/OTT.S91696 Text en © 2015 Qin et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Qin, Haifeng
Sha, Jiping
Jiang, Caixia
Gao, Xuemei
Qu, Lili
Yan, Haiying
Xu, Tianjiao
Jiang, Qiyu
Gao, Hongjun
miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
title miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
title_full miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
title_fullStr miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
title_full_unstemmed miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
title_short miR-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
title_sort mir-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631421/
https://www.ncbi.nlm.nih.gov/pubmed/26604787
http://dx.doi.org/10.2147/OTT.S91696
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