Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium

Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated transcription in Wnt pathway signaling. We studied effec...

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Detalles Bibliográficos
Autores principales: Feng, Ying, Sakamoto, Naoya, Wu, Rong, Liu, Jie-yu, Wiese, Alexandra, Green, Maranne E., Green, Megan, Akyol, Aytekin, Roy, Badal C., Zhai, Yali, Cho, Kathleen R., Fearon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631511/
https://www.ncbi.nlm.nih.gov/pubmed/26528816
http://dx.doi.org/10.1371/journal.pgen.1005638

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