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The wisdom of crowds and the repurposing of artesunate as an anticancer drug

Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-cli...

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Autores principales: Augustin, Yolanda, Krishna, Sanjeev, Kumar, Devinder, Pantziarka, Pan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631583/
https://www.ncbi.nlm.nih.gov/pubmed/26557887
http://dx.doi.org/10.3332/ecancer.2015.ed50
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author Augustin, Yolanda
Krishna, Sanjeev
Kumar, Devinder
Pantziarka, Pan
author_facet Augustin, Yolanda
Krishna, Sanjeev
Kumar, Devinder
Pantziarka, Pan
author_sort Augustin, Yolanda
collection PubMed
description Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-clinical evidence in a range of cancers, a recently completed randomised blinded trial in colorectal cancer has provided a positive signal for further clinical investigation. Used perioperatively artesunate appears to reduce the rate of disease recurrence - and the Neo-Art trial, a larger Phase II RCT, is seeking to confirm this positive effect. However, artesunate is a generic medication, and as with other trials of repurposed drugs, the Neo-Art trial does not have commercial sponsorship. In an innovative move, the trial is seeking funds directly from members of the public via a crowd-funding strategy that may have resonance beyond this single trial.
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spelling pubmed-46315832015-11-10 The wisdom of crowds and the repurposing of artesunate as an anticancer drug Augustin, Yolanda Krishna, Sanjeev Kumar, Devinder Pantziarka, Pan Ecancermedicalscience Editorial Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-clinical evidence in a range of cancers, a recently completed randomised blinded trial in colorectal cancer has provided a positive signal for further clinical investigation. Used perioperatively artesunate appears to reduce the rate of disease recurrence - and the Neo-Art trial, a larger Phase II RCT, is seeking to confirm this positive effect. However, artesunate is a generic medication, and as with other trials of repurposed drugs, the Neo-Art trial does not have commercial sponsorship. In an innovative move, the trial is seeking funds directly from members of the public via a crowd-funding strategy that may have resonance beyond this single trial. Cancer Intelligence 2015-10-13 /pmc/articles/PMC4631583/ /pubmed/26557887 http://dx.doi.org/10.3332/ecancer.2015.ed50 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Augustin, Yolanda
Krishna, Sanjeev
Kumar, Devinder
Pantziarka, Pan
The wisdom of crowds and the repurposing of artesunate as an anticancer drug
title The wisdom of crowds and the repurposing of artesunate as an anticancer drug
title_full The wisdom of crowds and the repurposing of artesunate as an anticancer drug
title_fullStr The wisdom of crowds and the repurposing of artesunate as an anticancer drug
title_full_unstemmed The wisdom of crowds and the repurposing of artesunate as an anticancer drug
title_short The wisdom of crowds and the repurposing of artesunate as an anticancer drug
title_sort wisdom of crowds and the repurposing of artesunate as an anticancer drug
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631583/
https://www.ncbi.nlm.nih.gov/pubmed/26557887
http://dx.doi.org/10.3332/ecancer.2015.ed50
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