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The wisdom of crowds and the repurposing of artesunate as an anticancer drug
Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-cli...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cancer Intelligence
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631583/ https://www.ncbi.nlm.nih.gov/pubmed/26557887 http://dx.doi.org/10.3332/ecancer.2015.ed50 |
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author | Augustin, Yolanda Krishna, Sanjeev Kumar, Devinder Pantziarka, Pan |
author_facet | Augustin, Yolanda Krishna, Sanjeev Kumar, Devinder Pantziarka, Pan |
author_sort | Augustin, Yolanda |
collection | PubMed |
description | Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-clinical evidence in a range of cancers, a recently completed randomised blinded trial in colorectal cancer has provided a positive signal for further clinical investigation. Used perioperatively artesunate appears to reduce the rate of disease recurrence - and the Neo-Art trial, a larger Phase II RCT, is seeking to confirm this positive effect. However, artesunate is a generic medication, and as with other trials of repurposed drugs, the Neo-Art trial does not have commercial sponsorship. In an innovative move, the trial is seeking funds directly from members of the public via a crowd-funding strategy that may have resonance beyond this single trial. |
format | Online Article Text |
id | pubmed-4631583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Cancer Intelligence |
record_format | MEDLINE/PubMed |
spelling | pubmed-46315832015-11-10 The wisdom of crowds and the repurposing of artesunate as an anticancer drug Augustin, Yolanda Krishna, Sanjeev Kumar, Devinder Pantziarka, Pan Ecancermedicalscience Editorial Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-clinical evidence in a range of cancers, a recently completed randomised blinded trial in colorectal cancer has provided a positive signal for further clinical investigation. Used perioperatively artesunate appears to reduce the rate of disease recurrence - and the Neo-Art trial, a larger Phase II RCT, is seeking to confirm this positive effect. However, artesunate is a generic medication, and as with other trials of repurposed drugs, the Neo-Art trial does not have commercial sponsorship. In an innovative move, the trial is seeking funds directly from members of the public via a crowd-funding strategy that may have resonance beyond this single trial. Cancer Intelligence 2015-10-13 /pmc/articles/PMC4631583/ /pubmed/26557887 http://dx.doi.org/10.3332/ecancer.2015.ed50 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Editorial Augustin, Yolanda Krishna, Sanjeev Kumar, Devinder Pantziarka, Pan The wisdom of crowds and the repurposing of artesunate as an anticancer drug |
title | The wisdom of crowds and the repurposing of artesunate as an anticancer drug |
title_full | The wisdom of crowds and the repurposing of artesunate as an anticancer drug |
title_fullStr | The wisdom of crowds and the repurposing of artesunate as an anticancer drug |
title_full_unstemmed | The wisdom of crowds and the repurposing of artesunate as an anticancer drug |
title_short | The wisdom of crowds and the repurposing of artesunate as an anticancer drug |
title_sort | wisdom of crowds and the repurposing of artesunate as an anticancer drug |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631583/ https://www.ncbi.nlm.nih.gov/pubmed/26557887 http://dx.doi.org/10.3332/ecancer.2015.ed50 |
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