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Heparan sulfate proteoglycans: a sugar code for vertebrate development?

Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG...

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Detalles Bibliográficos
Autores principales: Poulain, Fabienne E., Yost, H. Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631762/
https://www.ncbi.nlm.nih.gov/pubmed/26487777
http://dx.doi.org/10.1242/dev.098178
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author Poulain, Fabienne E.
Yost, H. Joseph
author_facet Poulain, Fabienne E.
Yost, H. Joseph
author_sort Poulain, Fabienne E.
collection PubMed
description Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG sugar chains have not yet been analyzed by genetics in vertebrates, recent studies have shown that HSPGs do indeed mediate a wide range of functions in early vertebrate development, for example during left-right patterning and in cardiovascular and neural development. Here, we provide a comprehensive overview of the various roles of HSPGs in these systems and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate development.
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spelling pubmed-46317622016-10-15 Heparan sulfate proteoglycans: a sugar code for vertebrate development? Poulain, Fabienne E. Yost, H. Joseph Development Review Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG sugar chains have not yet been analyzed by genetics in vertebrates, recent studies have shown that HSPGs do indeed mediate a wide range of functions in early vertebrate development, for example during left-right patterning and in cardiovascular and neural development. Here, we provide a comprehensive overview of the various roles of HSPGs in these systems and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate development. The Company of Biologists 2015-10-15 /pmc/articles/PMC4631762/ /pubmed/26487777 http://dx.doi.org/10.1242/dev.098178 Text en © 2015. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Poulain, Fabienne E.
Yost, H. Joseph
Heparan sulfate proteoglycans: a sugar code for vertebrate development?
title Heparan sulfate proteoglycans: a sugar code for vertebrate development?
title_full Heparan sulfate proteoglycans: a sugar code for vertebrate development?
title_fullStr Heparan sulfate proteoglycans: a sugar code for vertebrate development?
title_full_unstemmed Heparan sulfate proteoglycans: a sugar code for vertebrate development?
title_short Heparan sulfate proteoglycans: a sugar code for vertebrate development?
title_sort heparan sulfate proteoglycans: a sugar code for vertebrate development?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631762/
https://www.ncbi.nlm.nih.gov/pubmed/26487777
http://dx.doi.org/10.1242/dev.098178
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