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Heparan sulfate proteoglycans: a sugar code for vertebrate development?
Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631762/ https://www.ncbi.nlm.nih.gov/pubmed/26487777 http://dx.doi.org/10.1242/dev.098178 |
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author | Poulain, Fabienne E. Yost, H. Joseph |
author_facet | Poulain, Fabienne E. Yost, H. Joseph |
author_sort | Poulain, Fabienne E. |
collection | PubMed |
description | Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG sugar chains have not yet been analyzed by genetics in vertebrates, recent studies have shown that HSPGs do indeed mediate a wide range of functions in early vertebrate development, for example during left-right patterning and in cardiovascular and neural development. Here, we provide a comprehensive overview of the various roles of HSPGs in these systems and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate development. |
format | Online Article Text |
id | pubmed-4631762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Company of Biologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-46317622016-10-15 Heparan sulfate proteoglycans: a sugar code for vertebrate development? Poulain, Fabienne E. Yost, H. Joseph Development Review Heparan sulfate proteoglycans (HSPGs) have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions, both in vitro and in vivo in invertebrate models. Although many of the genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG sugar chains have not yet been analyzed by genetics in vertebrates, recent studies have shown that HSPGs do indeed mediate a wide range of functions in early vertebrate development, for example during left-right patterning and in cardiovascular and neural development. Here, we provide a comprehensive overview of the various roles of HSPGs in these systems and explore the concept of an instructive heparan sulfate sugar code for modulating vertebrate development. The Company of Biologists 2015-10-15 /pmc/articles/PMC4631762/ /pubmed/26487777 http://dx.doi.org/10.1242/dev.098178 Text en © 2015. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Poulain, Fabienne E. Yost, H. Joseph Heparan sulfate proteoglycans: a sugar code for vertebrate development? |
title | Heparan sulfate proteoglycans: a sugar code for vertebrate development? |
title_full | Heparan sulfate proteoglycans: a sugar code for vertebrate development? |
title_fullStr | Heparan sulfate proteoglycans: a sugar code for vertebrate development? |
title_full_unstemmed | Heparan sulfate proteoglycans: a sugar code for vertebrate development? |
title_short | Heparan sulfate proteoglycans: a sugar code for vertebrate development? |
title_sort | heparan sulfate proteoglycans: a sugar code for vertebrate development? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631762/ https://www.ncbi.nlm.nih.gov/pubmed/26487777 http://dx.doi.org/10.1242/dev.098178 |
work_keys_str_mv | AT poulainfabiennee heparansulfateproteoglycansasugarcodeforvertebratedevelopment AT yosthjoseph heparansulfateproteoglycansasugarcodeforvertebratedevelopment |