A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. However, the outcome of the disease varies markedly from individual to individual, even within the same tumor stage. This heterogeneity is governed to a great extent by the genetic make-up of individual tumors...

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Detalles Bibliográficos
Autores principales: Buchert, Michael, Rohde, Franziska, Eissmann, Moritz, Tebbutt, Niall, Williams, Ben, Tan, Chin Wee, Owen, Alexander, Hirokawa, Yumiko, Gnann, Alexandra, Orend, Gertraud, Orner, Gayle, Dashwood, Rod H., Heath, Joan K., Ernst, Matthias, Janssen, Klaus-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631784/
https://www.ncbi.nlm.nih.gov/pubmed/26398937
http://dx.doi.org/10.1242/dmm.019844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631784/
https://www.ncbi.nlm.nih.gov/pubmed/26398937
http://dx.doi.org/10.1242/dmm.019844

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