The Consequences of Replicating in the Wrong Orientation: Bacterial Chromosome Duplication without an Active Replication Origin

Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli, the DnaA initiator protein regulates the assembly of replication forks at oriC. This regulation can be undermined by defects in nucleic acid metabolism. I...

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Detalles Bibliográficos
Autores principales: Dimude, Juachi U., Stockum, Anna, Midgley-Smith, Sarah L., Upton, Amy L., Foster, Helen A., Khan, Arshad, Saunders, Nigel J., Retkute, Renata, Rudolph, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631800/
https://www.ncbi.nlm.nih.gov/pubmed/26530381
http://dx.doi.org/10.1128/mBio.01294-15

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