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Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

The cytochrome P450, CYP2C8, metabolizes more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However, predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recen...

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Detalles Bibliográficos
Autores principales:	Thomas, Maria, Winter, Stefan, Klumpp, Britta, Turpeinen, Miia, Klein, Kathrin, Schwab, Matthias, Zanger, Ulrich M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631943/ https://www.ncbi.nlm.nih.gov/pubmed/26582990 http://dx.doi.org/10.3389/fphar.2015.00261

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