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Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations

Mathematical models of metabolism from bacterial systems biology have proven their utility across multiple fields, for example metabolic engineering, growth phenotype simulation, and biological discovery. The usefulness of the models stems from their ability to compute a link between genotype and ph...

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Detalles Bibliográficos
Autores principales:	Aziz, Ramy K., Monk, Jonathan M., Lewis, Robert M., In Loh, Suh, Mishra, Arti, Abhay Nagle, Amrita, Satyanarayana, Chitkala, Dhakshinamoorthy, Saravanakumar, Luche, Michele, Kitchen, Douglas B., Andrews, Kathleen A., Fong, Nicole L., Li, Howard J., Palsson, Bernhard O., Charusanti, Pep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631998/ https://www.ncbi.nlm.nih.gov/pubmed/26531810 http://dx.doi.org/10.1038/srep16025

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