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The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila
Polyglutamine (pQ) tracts are abundant in proteins co-interacting on DNA. The lengths of these pQ tracts can modulate their interaction strengths. However, pQ tracts >40 residues are pathologically prone to amyloidogenic self-assembly. Here, we assess the extent and consequences of variation in t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632060/ https://www.ncbi.nlm.nih.gov/pubmed/26362765 http://dx.doi.org/10.1534/g3.115.021659 |