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The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila

Polyglutamine (pQ) tracts are abundant in proteins co-interacting on DNA. The lengths of these pQ tracts can modulate their interaction strengths. However, pQ tracts >40 residues are pathologically prone to amyloidogenic self-assembly. Here, we assess the extent and consequences of variation in t...

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Detalles Bibliográficos
Autores principales:	Rice, Clinton, Beekman, Danielle, Liu, Liping, Erives, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2015
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632060/ https://www.ncbi.nlm.nih.gov/pubmed/26362765 http://dx.doi.org/10.1534/g3.115.021659

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