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Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

Diacylglycerol kinases (DGKs) transform diacylglycerol (DAG) into phosphatidic acid (PA), balancing the levels of these key metabolic and signaling lipids. We previously showed that PA derived from the DGKζ isoform promotes mammalian target of rapamycin complex 1 (mTORC1) activation. This function m...

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Detalles Bibliográficos
Autores principales:	Torres-Ayuso, P, Tello-Lafoz, M, Mérida, I, Ávila-Flores, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632073/ https://www.ncbi.nlm.nih.gov/pubmed/26302180 http://dx.doi.org/10.1038/oncsis.2015.22

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