Dual subcellular compartment delivery of doxorubicin to overcome drug resistant and enhance antitumor activity

In order to overcome drug resistant and enhance antitumor activity of DOX, a new pH-sensitive micelle (DOX/DQA-DOX@DSPE-hyd-PEG-AA) was prepared to simultaneously deliver DOX to nucleus and mitochondria. Drug released from DOX/DQA-DOX@DSPE-hyd-PEG-AA showed a pH-dependent manner. DOX/DQA-DOX@DSPE-hy...

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Detalles Bibliográficos
Autores principales: Song, Yan-feng, Liu, Dao-zhou, Cheng, Ying, Liu, Miao, Ye, Wei-liang, Zhang, Bang-le, Liu, Xin-you, Zhou, Si-yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632084/
https://www.ncbi.nlm.nih.gov/pubmed/26530454
http://dx.doi.org/10.1038/srep16125

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