PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and apoptosis. Interest in targeting the PI3K signaling cascade continues, as new agents are being clinically evaluated. PI...

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Detalles Bibliográficos
Autores principales: Payne, S N, Maher, M E, Tran, N H, Van De Hey, D R, Foley, T M, Yueh, A E, Leystra, A A, Pasch, C A, Jeffrey, J J, Clipson, L, Matkowskyj, K A, Deming, D A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632089/
https://www.ncbi.nlm.nih.gov/pubmed/26436951
http://dx.doi.org/10.1038/oncsis.2015.28

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