PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids

OBJECTIVES: Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism. Islets of type 2 diabetic subjects have reduced PGC-1α expression and this is associated with decreased insulin secretion, ye...

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Detalles Bibliográficos
Autores principales: Oropeza, Daniel, Jouvet, Nathalie, Bouyakdan, Khalil, Perron, Gabrielle, Ringuette, Lea-Jeanne, Philipson, Louis H., Kiss, Robert S., Poitout, Vincent, Alquier, Thierry, Estall, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632114/
https://www.ncbi.nlm.nih.gov/pubmed/26629405
http://dx.doi.org/10.1016/j.molmet.2015.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632114/
https://www.ncbi.nlm.nih.gov/pubmed/26629405
http://dx.doi.org/10.1016/j.molmet.2015.08.001

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