Cargando…

PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids

OBJECTIVES: Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism. Islets of type 2 diabetic subjects have reduced PGC-1α expression and this is associated with decreased insulin secretion, ye...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oropeza, Daniel, Jouvet, Nathalie, Bouyakdan, Khalil, Perron, Gabrielle, Ringuette, Lea-Jeanne, Philipson, Louis H., Kiss, Robert S., Poitout, Vincent, Alquier, Thierry, Estall, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632114/ https://www.ncbi.nlm.nih.gov/pubmed/26629405 http://dx.doi.org/10.1016/j.molmet.2015.08.001

Ejemplares similares

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice
por: Jouvet, Nathalie, et al.
Publicado: (2021)

Phenotypic Characterization of MIP-CreERT(1Lphi) Mice With Transgene-Driven Islet Expression of Human Growth Hormone
por: Oropeza, Daniel, et al.
Publicado: (2015)

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding
por: Kebede, Melkam, et al.
Publicado: (2008)

GPR40: Good Cop, Bad Cop?
por: Alquier, Thierry, et al.
Publicado: (2009)

Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1β
por: Liesa, Marc, et al.
Publicado: (2008)

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
por: Léveillé, Mélissa, et al.
Publicado: (2020)

Dynamic Distribution of Nuclear Coactivator 4 during Mitosis: Association with Mitotic Apparatus and Midbodies
por: Kollara, Alexandra, et al.
Publicado: (2011)

Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
por: Kamimura, Naomi, et al.
Publicado: (2016)

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α
por: Kim, Jihyun, et al.
Publicado: (2016)

Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α
por: Bhalla, Kavita, et al.
Publicado: (2014)

The regulatory role of PGC1α‐related coactivator in response to drug‐induced liver injury
por: Buler, Marcin, et al.
Publicado: (2020)

Transcriptional coactivator NT‐PGC‐1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis
por: Chang, Ji Suk, et al.
Publicado: (2016)

PGC1 alpha coactivates ERG fusion to drive antioxidant target genes under metabolic stress
por: Dhara, Aiindrila, et al.
Publicado: (2022)

Transcriptional orchestration of mitochondrial homeostasis in a cellular model of PGC-1-related coactivator-dependent thyroid tumor
por: Dumont, Solenne, et al.
Publicado: (2018)

Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice
por: Auguste, Stéphanie, et al.
Publicado: (2016)

The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1
por: Xu, L, et al.
Publicado: (2016)

PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
por: Mackenzie-Gray Scott, Connie, et al.
Publicado: (2022)

Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
por: Alquier, Thierry, et al.
Publicado: (2009)

Essential roles for the nuclear receptor coactivator Ncoa3 in pluripotency
por: Percharde, Michelle, et al.
Publicado: (2013)

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression
por: Cho, Hana, et al.
Publicado: (2018)

Transcriptional coactivator PGC-1α contributes to decidualization by forming a histone-modifying complex with C/EBPβ and p300
por: Takagi, Haruka, et al.
Publicado: (2022)

PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin
por: Besse-Patin, Aurèle, et al.
Publicado: (2019)

PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes
por: Tuomainen, Tomi, et al.
Publicado: (2022)

Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice
por: Fergusson, Grace, et al.
Publicado: (2014)

PGC-1-Related Coactivator Modulates Mitochondrial-Nuclear Crosstalk through Endogenous Nitric Oxide in a Cellular Model of Oncocytic Thyroid Tumours
por: Raharijaona, Mahatsangy, et al.
Publicado: (2009)

Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization
por: Kommagani, Ramakrishna, et al.
Publicado: (2013)

Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses
por: Gouspillou, Gilles, et al.
Publicado: (2013)

A key role of PGC‐1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA‐Cl in cultured human fibroblasts
por: Igarashi, Junsuke, et al.
Publicado: (2016)

Aqueous Extract of Paris polyphylla (AEPP) Inhibits Ovarian Cancer via Suppression of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator (PGC)-1alpha
por: Wang, Chia-Woei, et al.
Publicado: (2016)

Molecular Characterization of PGC-1β (PPAR Gamma Coactivator 1β) and its Roles in Mitochondrial Biogenesis in Blunt Snout Bream (Megalobrama amblycephala)
por: Lu, Kangle, et al.
Publicado: (2020)

Corepressor/coactivator paradox: potential constitutive coactivation by corepressor splice variants
por: Meng, Xianwang, et al.
Publicado: (2006)

Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis
por: Abdelnabi, Mohamed N., et al.
Publicado: (2022)

p53‐Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio‐oncology
por: Saleme, Bruno, et al.
Publicado: (2020)

Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Enhances Engraftment and Angiogenesis of Mesenchymal Stem Cells in Diabetic Hindlimb Ischemia
por: Lu, Debin, et al.
Publicado: (2012)

Mitochondrial Biogenesis and Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation by Physical Activity: Intact Adipocytokine Signaling Is Required
por: Li, Ling, et al.
Publicado: (2011)

Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) overexpression alleviates endoplasmic reticulum stress after acute kidney injury
por: Pan, Hao, et al.
Publicado: (2022)

Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
por: Estall, Jennifer L., et al.
Publicado: (2009)

Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization
por: Kommagani, Ramakrishna, et al.
Publicado: (2015)

Microfibrillar-associated protein 5 suppresses adipogenesis by inhibiting essential coactivator of PPARγ
por: Zhang, Tianlong, et al.
Publicado: (2023)

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis
por: Zhao, Wei, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_eg5q7cro45kt1ajgg830435lp5