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Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats
Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about their mechanism. We utilized a communication box to establish an animal model of physiological stress (foot-...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632128/ https://www.ncbi.nlm.nih.gov/pubmed/26530305 http://dx.doi.org/10.1038/srep15976 |
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author | Yu, Bin Cui, Su-Ying Zhang, Xue-Qiong Cui, Xiang-Yu Li, Sheng-Jie Sheng, Zhao-Fu Cao, Qing Huang, Yuan-Li Xu, Ya-Ping Lin, Zhi-Ge Yang, Guang Song, Jin-Zhi Ding, Hui Zhang, Yong-He |
author_facet | Yu, Bin Cui, Su-Ying Zhang, Xue-Qiong Cui, Xiang-Yu Li, Sheng-Jie Sheng, Zhao-Fu Cao, Qing Huang, Yuan-Li Xu, Ya-Ping Lin, Zhi-Ge Yang, Guang Song, Jin-Zhi Ding, Hui Zhang, Yong-He |
author_sort | Yu, Bin |
collection | PubMed |
description | Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about their mechanism. We utilized a communication box to establish an animal model of physiological stress (foot-shock [FS]) and psychological stress (PS) to mimic the direct suffering and witnessing of traumatic events. Twenty-one days after traumatic stress, some of the experimental animals presented startled awakening (i.e., were startled awake by a supposed “nightmare”) with different electroencephalographic spectra features. Our neuroanatomical results showed that the secondary somatosensory cortex and primary auditory cortex may play an important role in remote traumatic memory retrieval in FS “nightmare” (FSN) rats, whereas the temporal association cortex may play an important role in PS “nightmare” (PSN) rats. The FSN and PSN groups possessed common emotion evocation circuits, including activation of the amygdala and inactivation of the infralimbic prefrontal cortex and ventral anterior cingulate cortex. The decreased activity of the granular and dysgranular insular cortex was only observed in PSN rats. The present results imply that different types of stress may cause PTSD-like “nightmares” in rodents and identified the possible neurocircuitry of memory retrieval and emotion evocation. |
format | Online Article Text |
id | pubmed-4632128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46321282015-11-05 Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats Yu, Bin Cui, Su-Ying Zhang, Xue-Qiong Cui, Xiang-Yu Li, Sheng-Jie Sheng, Zhao-Fu Cao, Qing Huang, Yuan-Li Xu, Ya-Ping Lin, Zhi-Ge Yang, Guang Song, Jin-Zhi Ding, Hui Zhang, Yong-He Sci Rep Article Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about their mechanism. We utilized a communication box to establish an animal model of physiological stress (foot-shock [FS]) and psychological stress (PS) to mimic the direct suffering and witnessing of traumatic events. Twenty-one days after traumatic stress, some of the experimental animals presented startled awakening (i.e., were startled awake by a supposed “nightmare”) with different electroencephalographic spectra features. Our neuroanatomical results showed that the secondary somatosensory cortex and primary auditory cortex may play an important role in remote traumatic memory retrieval in FS “nightmare” (FSN) rats, whereas the temporal association cortex may play an important role in PS “nightmare” (PSN) rats. The FSN and PSN groups possessed common emotion evocation circuits, including activation of the amygdala and inactivation of the infralimbic prefrontal cortex and ventral anterior cingulate cortex. The decreased activity of the granular and dysgranular insular cortex was only observed in PSN rats. The present results imply that different types of stress may cause PTSD-like “nightmares” in rodents and identified the possible neurocircuitry of memory retrieval and emotion evocation. Nature Publishing Group 2015-11-04 /pmc/articles/PMC4632128/ /pubmed/26530305 http://dx.doi.org/10.1038/srep15976 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Yu, Bin Cui, Su-Ying Zhang, Xue-Qiong Cui, Xiang-Yu Li, Sheng-Jie Sheng, Zhao-Fu Cao, Qing Huang, Yuan-Li Xu, Ya-Ping Lin, Zhi-Ge Yang, Guang Song, Jin-Zhi Ding, Hui Zhang, Yong-He Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats |
title | Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats |
title_full | Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats |
title_fullStr | Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats |
title_full_unstemmed | Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats |
title_short | Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats |
title_sort | different neural circuitry is involved in physiological and psychological stress-induced ptsd-like “nightmares” in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632128/ https://www.ncbi.nlm.nih.gov/pubmed/26530305 http://dx.doi.org/10.1038/srep15976 |
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