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Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging

BACKGROUND: Diffusion-weighted imaging (DWI) is a noninvasive method for investigation of tumor histological content. It has been applied for some musculoskeletal tumors and reported to be useful. OBJECTIVES: The aim of the present study was to prospectively evaluate the apparent diffusion coefficie...

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Autores principales: Pekcevik, Yeliz, Kahya, Mehmet Onur, Kaya, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632135/
https://www.ncbi.nlm.nih.gov/pubmed/26557269
http://dx.doi.org/10.5812/iranjradiol.15478v2
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author Pekcevik, Yeliz
Kahya, Mehmet Onur
Kaya, Ahmet
author_facet Pekcevik, Yeliz
Kahya, Mehmet Onur
Kaya, Ahmet
author_sort Pekcevik, Yeliz
collection PubMed
description BACKGROUND: Diffusion-weighted imaging (DWI) is a noninvasive method for investigation of tumor histological content. It has been applied for some musculoskeletal tumors and reported to be useful. OBJECTIVES: The aim of the present study was to prospectively evaluate the apparent diffusion coefficient (ADC) values of benign and malignant soft tissue tumors and to determine if ADC can help differentiate these tumors. PATIENTS AND METHODS: DWI was performed on 25 histologically proven soft tissue masses. It was obtained with a single-shot echo-planar imaging technique using a 1.5T magnetic resonance (MR) machine. The mean ADC values were calculated. We grouped soft tissue tumors as benign cystic, benign solid or mixed, malignant cystic and malignant solid or mixed tumors and compared mean ADC values between these groups. RESULTS: There was only one patient with a malignant cystic tumor and was not included in the statistical analysis. The median ADC values of benign and malignant tumors were 2.31 ± 1.29 and 0.90 ± 0.70 (median ± interquartile range), respectively. The mean ADC values were different between benign and malignant tumors (P = 0.031). Benign cystic tumors had significantly higher ADC values than benign solid or mixed tumors and malignant solid or mixed tumors (p values were < 0.001 and 0.003, respectively). Malignant solid or mixed tumors had lower ADC values than benign solid or mixed tumors (P = 0.02). CONCLUSION: Our preliminary results have shown that although there is some overlap between benign and malignant tumors, adding DWI, MR imaging to routine soft tissue tumor protocols may improve diagnostic accuracy.
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spelling pubmed-46321352015-11-09 Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging Pekcevik, Yeliz Kahya, Mehmet Onur Kaya, Ahmet Iran J Radiol Musculoskeletal Imaging BACKGROUND: Diffusion-weighted imaging (DWI) is a noninvasive method for investigation of tumor histological content. It has been applied for some musculoskeletal tumors and reported to be useful. OBJECTIVES: The aim of the present study was to prospectively evaluate the apparent diffusion coefficient (ADC) values of benign and malignant soft tissue tumors and to determine if ADC can help differentiate these tumors. PATIENTS AND METHODS: DWI was performed on 25 histologically proven soft tissue masses. It was obtained with a single-shot echo-planar imaging technique using a 1.5T magnetic resonance (MR) machine. The mean ADC values were calculated. We grouped soft tissue tumors as benign cystic, benign solid or mixed, malignant cystic and malignant solid or mixed tumors and compared mean ADC values between these groups. RESULTS: There was only one patient with a malignant cystic tumor and was not included in the statistical analysis. The median ADC values of benign and malignant tumors were 2.31 ± 1.29 and 0.90 ± 0.70 (median ± interquartile range), respectively. The mean ADC values were different between benign and malignant tumors (P = 0.031). Benign cystic tumors had significantly higher ADC values than benign solid or mixed tumors and malignant solid or mixed tumors (p values were < 0.001 and 0.003, respectively). Malignant solid or mixed tumors had lower ADC values than benign solid or mixed tumors (P = 0.02). CONCLUSION: Our preliminary results have shown that although there is some overlap between benign and malignant tumors, adding DWI, MR imaging to routine soft tissue tumor protocols may improve diagnostic accuracy. Kowsar 2015-07-22 /pmc/articles/PMC4632135/ /pubmed/26557269 http://dx.doi.org/10.5812/iranjradiol.15478v2 Text en Copyright © 2015, Tehran University of Medical Sciences and Iranian Society of Radiology. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Musculoskeletal Imaging
Pekcevik, Yeliz
Kahya, Mehmet Onur
Kaya, Ahmet
Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging
title Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging
title_full Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging
title_fullStr Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging
title_full_unstemmed Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging
title_short Characterization of Soft Tissue Tumors by Diffusion-Weighted Imaging
title_sort characterization of soft tissue tumors by diffusion-weighted imaging
topic Musculoskeletal Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632135/
https://www.ncbi.nlm.nih.gov/pubmed/26557269
http://dx.doi.org/10.5812/iranjradiol.15478v2
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