Cargando…

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6()

OBJECTIVE: Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss- and gain-of-function studies have generated confou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Jason G., Ramadori, Giorgio, Ioris, Rafael M., Galiè, Mirco, Berglund, Eric D., Coate, Katie C., Fujikawa, Teppei, Pucciarelli, Stefania, Moreschini, Benedetta, Amici, Augusto, Andreani, Cristina, Coppari, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632175/ https://www.ncbi.nlm.nih.gov/pubmed/26629408 http://dx.doi.org/10.1016/j.molmet.2015.09.003

Ejemplares similares

Does hypothalamic SIRT1 regulate aging?
por: Ramadori, Giorgio, et al.
Publicado: (2011)

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity
por: Ioris, Rafael M., et al.
Publicado: (2017)

Hypothalamic-mediated control of glucose balance in the presence and absence of insulin
por: Fujikawa, Teppei, et al.
Publicado: (2014)

Living without insulin: the role of leptin signaling in the hypothalamus
por: Fujikawa, Teppei, et al.
Publicado: (2015)

Diet-Induced Unresolved ER Stress Hinders KRAS-Driven Lung Tumorigenesis
por: Ramadori, Giorgio, et al.
Publicado: (2015)

Mesenchymal/Stromal Gene Expression Signature Relates to Basal-Like Breast Cancers, Identifies Bone Metastasis and Predicts Resistance to Therapies
por: Marchini, Cristina, et al.
Publicado: (2010)

S100A9 extends lifespan in insulin deficiency
por: Ramadori, Giorgio, et al.
Publicado: (2019)

The physiological roles of Sirt1 in skeletal muscle
por: Pardo, Patricia S., et al.
Publicado: (2011)

Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
por: Brenachot, Xavier, et al.
Publicado: (2017)

Overexpression of SIRT1 in Rat Skeletal Muscle Does Not Alter Glucose Induced Insulin Resistance
por: Brandon, Amanda E., et al.
Publicado: (2015)

AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance
por: Vilà, Laia, et al.
Publicado: (2016)

Breast Cancer Treatment: The Case of Gold(I)-Based Compounds as a Promising Class of Bioactive Molecules
por: Galassi, Rossana, et al.
Publicado: (2022)

Evaluation of Different DNA Vaccines against Porcine Reproductive and Respiratory Syndrome (PRRS) in Pigs
por: Petrini, Stefano, et al.
Publicado: (2013)

Multi-Targeted Anticancer Activity of Imidazolate Phosphane Gold(I) Compounds by Inhibition of DHFR and TrxR in Breast Cancer Cells
por: Galassi, Rossana, et al.
Publicado: (2021)

RAS as Supporting Actor in Breast Cancer
por: Galiè, Mirco
Publicado: (2019)

Editorial: The Roles of Oncogenic Phosphatase/Kinase in Tumors
por: Galiè, Mirco
Publicado: (2022)

Studies on the Interaction between Poly-Phosphane Gold(I) Complexes and Dihydrofolate Reductase: An Interplay with Nicotinamide Adenine Dinucleotide Cofactor
por: Pucciarelli, Stefania, et al.
Publicado: (2019)

Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells
por: Wang, Yadong, et al.
Publicado: (2017)

Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression
por: Wang, Xiaofei, et al.
Publicado: (2016)

Regulation of Skeletal Muscle Oxidative Capacity and Muscle Mass by SIRT3
por: Lin, Ligen, et al.
Publicado: (2014)

The role of SIRT1 in skeletal muscle function and repair of older mice
por: Myers, Matthew J., et al.
Publicado: (2019)

SIRT3 Overexpression Attenuates Palmitate-Induced Pancreatic β-Cell Dysfunction
por: Kim, Min, et al.
Publicado: (2015)

SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
por: Ma, Ming-Chun, et al.
Publicado: (2018)

Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age
por: Machin, Daniel R., et al.
Publicado: (2020)

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation
por: Escalona-Garrido, Carmen, et al.
Publicado: (2020)

Sirtuin (Sirt) 3 Overexpression Prevents Retinopathy in Streptozotocin-Induced Diabetic Rats
por: Mao, Xin-bang, et al.
Publicado: (2020)

Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice
por: Xu, Kang, et al.
Publicado: (2020)

SIRT1 regulates nuclear number and domain size in skeletal muscle fibers
por: Ross, Jacob A., et al.
Publicado: (2018)

Oxidative Stress in Skeletal Muscle
por: Fanò-Illic, Giorgio, et al.
Publicado: (2022)

Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
por: Wu, Dongmei, et al.
Publicado: (2011)

Overexpression of SIRT1 and induction of apoptosis by its inhibition in adult T-cell leukemia cells
por: Kozako, Tomohiro, et al.
Publicado: (2011)

Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
por: Hao, Chong, et al.
Publicado: (2014)

Combination of SIRT1 and Src overexpression suggests poor prognosis in luminal breast cancer
por: Tan, Jie, et al.
Publicado: (2018)

Sirt1 overexpression attenuates Western‐style diet‐induced aortic stiffening in mice
por: Gogulamudi, Venkateswara R., et al.
Publicado: (2022)

VMHdm/c(SF-1) neuronal circuits regulate skeletal muscle PGC1-α via the sympathoadrenal drive
por: Yoshida, Takuya, et al.
Publicado: (2023)

CIVIT dataset: Integral microscopy with Fourier plane recording
por: Moreschini, Sergio, et al.
Publicado: (2022)

The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure
por: Galiè, Mirco, et al.
Publicado: (2019)

SIRT3 in Cardiac Physiology and Disease
por: Koentges, Christoph, et al.
Publicado: (2016)

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway
por: Zhang, Bin, et al.
Publicado: (2013)

Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise
por: Williams, Cameron B, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_e1u12kmfpg73uae75d1jq8tu56