Time-Delayed Models of Gene Regulatory Networks

We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternative modelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks...

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Detalles Bibliográficos
Autores principales: Parmar, K., Blyuss, K. B., Kyrychko, Y. N., Hogan, S. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632181/
https://www.ncbi.nlm.nih.gov/pubmed/26576197
http://dx.doi.org/10.1155/2015/347273
Descripción
Sumario:We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternative modelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems.

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