Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by the Nek9 non-catalytic C-terminal domain (CTD). CTD binding apparently releases autoinhibition because mutation...

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Detalles Bibliográficos
Autores principales: Haq, Tamanna, Richards, Mark W., Burgess, Selena G., Gallego, Pablo, Yeoh, Sharon, O'Regan, Laura, Reverter, David, Roig, Joan, Fry, Andrew M., Bayliss, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632185/
https://www.ncbi.nlm.nih.gov/pubmed/26522158
http://dx.doi.org/10.1038/ncomms9771

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