p53 regulates the mevalonate pathway in human glioblastoma multiforme

The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway including 3′-hydroxy-3′-methylglutaryl-coenzyme A reductase, MVA kinase, farnes...

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Detalles Bibliográficos
Autores principales: Laezza, C, D'Alessandro, A, Di Croce, L, Picardi, P, Ciaglia, E, Pisanti, S, Malfitano, A M, Comegna, M, Faraonio, R, Gazzerro, P, Bifulco, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632304/
https://www.ncbi.nlm.nih.gov/pubmed/26469958
http://dx.doi.org/10.1038/cddis.2015.279

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