Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome

BACKGROUND: Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART and resulted in...

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Detalles Bibliográficos
Autores principales: Wei, Shijie, Ji, Hongyan, Yang, Bei, Ma, Liping, Bei, Zhuchun, Li, Xiang, Dang, Hongwan, Yang, Xiaoying, Liu, Cheng, Wu, Xiuli, Chen, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632357/
https://www.ncbi.nlm.nih.gov/pubmed/26537009
http://dx.doi.org/10.1186/s12936-015-0929-3

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