Cargando…

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants

Within-host genetic sequencing from samples collected over time provides a dynamic view of how viruses evade host immunity. Immune-driven mutations might stimulate neutralization breadth by selecting antibodies adapted to cycles of immune escape that generate within-subject epitope diversity. Compre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hraber, Peter, Korber, Bette, Wagh, Kshitij, Giorgi, Elena E., Bhattacharya, Tanmoy, Gnanakaran, S., Lapedes, Alan S., Learn, Gerald H., Kreider, Edward F., Li, Yingying, Shaw, George M., Hahn, Beatrice H., Montefiori, David C., Alam, S. Munir, Bonsignori, Mattia, Moody, M. Anthony, Liao, Hua-Xin, Gao, Feng, Haynes, Barton F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632389/ https://www.ncbi.nlm.nih.gov/pubmed/26506369 http://dx.doi.org/10.3390/v7102881

Ejemplares similares

A single, continuous metric to define tiered serum neutralization potency against HIV
por: Hraber, Peter, et al.
Publicado: (2018)

Polyvalent vaccine approaches to combat HIV‐1 diversity
por: Korber, Bette, et al.
Publicado: (2017)

Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies
por: Gnanakaran, S., et al.
Publicado: (2010)

P04-54 LB. Genetic signature analysis identifies the CD4i region of gp120 as a determinant of broadly NAb responses in HIV-1-infected individuals
por: Gnanakaran, G, et al.
Publicado: (2009)

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth
por: Wagh, Kshitij, et al.
Publicado: (2018)

A Signature in HIV-1 Envelope Leader Peptide Associated with Transition from Acute to Chronic Infection Impacts Envelope Processing and Infectivity
por: Asmal, Mohammed, et al.
Publicado: (2011)

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1
por: Keele, Brandon F., et al.
Publicado: (2009)

Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing
por: Li, Hui, et al.
Publicado: (2012)

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design
por: Bricault, Christine A., et al.
Publicado: (2019)

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design
por: Bricault, Christine A., et al.
Publicado: (2019)

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines
por: Shen, Xiaoying, et al.
Publicado: (2021)

Some conceptual designs for a LASSY spectrometer magnet
por: Green, M A
Publicado: (1995)

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines
por: Shen, Xiaoying, et al.
Publicado: (2021)

Antibody‐virus co‐evolution in HIV infection: paths for HIV vaccine development
por: Bonsignori, Mattia, et al.
Publicado: (2017)

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
por: Haynes, Barton F., et al.
Publicado: (2022)

LASSIE: simulating large-scale models of biochemical systems on GPUs
por: Tangherloni, Andrea, et al.
Publicado: (2017)

The SARS-CoV-2 Spike variant D614G favors an open conformational state
por: Mansbach, Rachael A., et al.
Publicado: (2021)

Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage
por: Henderson, Rory, et al.
Publicado: (2023)

LASSI: A lattice model for simulating phase transitions of multivalent proteins
por: Choi, Jeong-Mo, et al.
Publicado: (2019)

HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC
por: Wood, Natasha, et al.
Publicado: (2009)

The SARS-CoV-2 Spike Variant D614G Favors an Open Conformational State
por: Mansbach, Rachael A., et al.
Publicado: (2021)

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection
por: Wagh, Kshitij, et al.
Publicado: (2016)

Estimating the Timing of Early Simian-Human Immunodeficiency Virus Infections: a Comparison between Poisson Fitter and BEAST
por: Giorgi, Elena E., et al.
Publicado: (2020)

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
por: Goonetilleke, Nilu, et al.
Publicado: (2009)

High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men
por: Li, Hui, et al.
Publicado: (2010)

Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity [ADCC] Responses
por: Pollara, Justin, et al.
Publicado: (2013)

Estimating time since infection in early homogeneous HIV-1 samples using a poisson model
por: Giorgi, Elena E, et al.
Publicado: (2010)

Genital Tract Sequestration of SIV following Acute Infection
por: Whitney, James B., et al.
Publicado: (2011)

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates
por: Cai, Fangping, et al.
Publicado: (2021)

Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing
por: Fischer, Will, et al.
Publicado: (2010)

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection
por: Song, Hongshuo, et al.
Publicado: (2018)

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function
por: Stanicek, Laura, et al.
Publicado: (2020)

Ambient noise Love wave attenuation tomography for the LASSIE array across the Los Angeles basin
por: Liu, Xin, et al.
Publicado: (2021)

Coping with Viral Diversity in HIV Vaccine Design: A Response to Nickle et al
por: Fischer, Will, et al.
Publicado: (2008)

Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate
por: Ribeiro, Ruy M., et al.
Publicado: (2012)

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations
por: Han, Qifeng, et al.
Publicado: (2019)

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice
por: Mu, Zekun, et al.
Publicado: (2022)

A Mechanistic Understanding of Allosteric Immune Escape Pathways in the HIV-1 Envelope Glycoprotein
por: Sethi, Anurag, et al.
Publicado: (2013)

Impact of mutations near the SARS-CoV-2 furin-cleavage site on viral infectivity
por: Nguyen, Kien, et al.
Publicado: (2022)

P09-21 LB. Deep sequencing of HIV-1 from acute infection: low initial diversity, and rapid but variable CTL escape
por: Fischer, W, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_h468aolmc2pck1mj42ogc6oir8