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Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones

ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacterial activity against the human pathogenic bacterium...

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Detalles Bibliográficos
Autores principales:	Skouloubris, Stéphane, Djaout, Kamel, Lamarre, Isabelle, Lambry, Jean-Christophe, Anger, Karine, Briffotaux, Julien, Liebl, Ursula, de Reuse, Hilde, Myllykallio, Hannu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632503/ https://www.ncbi.nlm.nih.gov/pubmed/26040760 http://dx.doi.org/10.1098/rsob.150015

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