The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells

INTRODUCTION: The A673T mutation in the amyloid precursor protein (APP) protects against Alzheimer’s disease by reducing β-amyloid protein (Aβ) production. This mutation reduced the release of the soluble APP fragment (sAPPβ), which is processed by β-secretase, suggesting a concomitant decrease in t...

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Detalles Bibliográficos
Autores principales: Kokawa, Asuka, Ishihara, Seiko, Fujiwara, Hitomi, Nobuhara, Mika, Iwata, Minori, Ihara, Yasuo, Funamoto, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632685/
https://www.ncbi.nlm.nih.gov/pubmed/26531305
http://dx.doi.org/10.1186/s40478-015-0247-6

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