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Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells

In recent years, there has been an increased interest in the design and use of iron oxide materials with nanoscale dimensions for magnetic, catalytic, biomedical, and electronic applications. The increased manufacture and use of iron oxide nanoparticles (IONPs) in consumer products as well as indust...

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Autores principales: Dissanayake, Niluka M., Current, Kelley M., Obare, Sherine O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632710/
https://www.ncbi.nlm.nih.gov/pubmed/26437397
http://dx.doi.org/10.3390/ijms161023482
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author Dissanayake, Niluka M.
Current, Kelley M.
Obare, Sherine O.
author_facet Dissanayake, Niluka M.
Current, Kelley M.
Obare, Sherine O.
author_sort Dissanayake, Niluka M.
collection PubMed
description In recent years, there has been an increased interest in the design and use of iron oxide materials with nanoscale dimensions for magnetic, catalytic, biomedical, and electronic applications. The increased manufacture and use of iron oxide nanoparticles (IONPs) in consumer products as well as industrial processes is expected to lead to the unintentional release of IONPs into the environment. The impact of IONPs on the environment and on biological species is not well understood but remains a concern due to the increased chemical reactivity of nanoparticles relative to their bulk counterparts. This review article describes the impact of IONPs on cellular genetic components. The mutagenic impact of IONPs may damage an organism’s ability to develop or reproduce. To date, there has been experimental evidence of IONPs having mutagenic interactions on human cell lines including lymphoblastoids, fibroblasts, microvascular endothelial cells, bone marrow cells, lung epithelial cells, alveolar type II like epithelial cells, bronchial fibroblasts, skin epithelial cells, hepatocytes, cerebral endothelial cells, fibrosarcoma cells, breast carcinoma cells, lung carcinoma cells, and cervix carcinoma cells. Other cell lines including the Chinese hamster ovary cells, mouse fibroblast cells, murine fibroblast cells, Mytilus galloprovincialis sperm cells, mice lung cells, murine alveolar macrophages, mice hepatic and renal tissue cells, and vero cells have also shown mutagenic effects upon exposure to IONPs. We further show the influence of IONPs on microorganisms in the presence and absence of dissolved organic carbon. The results shed light on the transformations IONPs undergo in the environment and the nature of the potential mutagenic impact on biological cells.
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spelling pubmed-46327102015-11-23 Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells Dissanayake, Niluka M. Current, Kelley M. Obare, Sherine O. Int J Mol Sci Review In recent years, there has been an increased interest in the design and use of iron oxide materials with nanoscale dimensions for magnetic, catalytic, biomedical, and electronic applications. The increased manufacture and use of iron oxide nanoparticles (IONPs) in consumer products as well as industrial processes is expected to lead to the unintentional release of IONPs into the environment. The impact of IONPs on the environment and on biological species is not well understood but remains a concern due to the increased chemical reactivity of nanoparticles relative to their bulk counterparts. This review article describes the impact of IONPs on cellular genetic components. The mutagenic impact of IONPs may damage an organism’s ability to develop or reproduce. To date, there has been experimental evidence of IONPs having mutagenic interactions on human cell lines including lymphoblastoids, fibroblasts, microvascular endothelial cells, bone marrow cells, lung epithelial cells, alveolar type II like epithelial cells, bronchial fibroblasts, skin epithelial cells, hepatocytes, cerebral endothelial cells, fibrosarcoma cells, breast carcinoma cells, lung carcinoma cells, and cervix carcinoma cells. Other cell lines including the Chinese hamster ovary cells, mouse fibroblast cells, murine fibroblast cells, Mytilus galloprovincialis sperm cells, mice lung cells, murine alveolar macrophages, mice hepatic and renal tissue cells, and vero cells have also shown mutagenic effects upon exposure to IONPs. We further show the influence of IONPs on microorganisms in the presence and absence of dissolved organic carbon. The results shed light on the transformations IONPs undergo in the environment and the nature of the potential mutagenic impact on biological cells. MDPI 2015-09-30 /pmc/articles/PMC4632710/ /pubmed/26437397 http://dx.doi.org/10.3390/ijms161023482 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dissanayake, Niluka M.
Current, Kelley M.
Obare, Sherine O.
Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells
title Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells
title_full Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells
title_fullStr Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells
title_full_unstemmed Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells
title_short Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells
title_sort mutagenic effects of iron oxide nanoparticles on biological cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632710/
https://www.ncbi.nlm.nih.gov/pubmed/26437397
http://dx.doi.org/10.3390/ijms161023482
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