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Identification and Validation of Aspartic Acid Semialdehyde Dehydrogenase as a New Anti-Mycobacterium Tuberculosis Target

Aspartic acid semialdehyde dehydrogenase (ASADH) lies at the first branch point in the essential aspartic acid biosynthetic pathway that is found in bacteria and plants but is absent from animals. Mutations in the asadh gene encoding ASADH produce an inactive enzyme, which is lethal. Therefore, in t...

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Detalles Bibliográficos
Autores principales:	Meng, Jianzhou, Yang, Yanhui, Xiao, Chunling, Guan, Yan, Hao, Xueqin, Deng, Qi, Lu, Zhongyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632714/ https://www.ncbi.nlm.nih.gov/pubmed/26437401 http://dx.doi.org/10.3390/ijms161023572

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