MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD

MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Ce...

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Detalles Bibliográficos
Autores principales: Cai, Donghui, He, Kang, Chang, Su’e, Tong, Dongdong, Huang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632720/
https://www.ncbi.nlm.nih.gov/pubmed/26457704
http://dx.doi.org/10.3390/ijms161023668
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author Cai, Donghui
He, Kang
Chang, Su’e
Tong, Dongdong
Huang, Chen
author_facet Cai, Donghui
He, Kang
Chang, Su’e
Tong, Dongdong
Huang, Chen
author_sort Cai, Donghui
collection PubMed
description MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU) sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity.
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spelling pubmed-46327202015-11-23 MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD Cai, Donghui He, Kang Chang, Su’e Tong, Dongdong Huang, Chen Int J Mol Sci Article MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU) sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity. MDPI 2015-10-06 /pmc/articles/PMC4632720/ /pubmed/26457704 http://dx.doi.org/10.3390/ijms161023668 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cai, Donghui
He, Kang
Chang, Su’e
Tong, Dongdong
Huang, Chen
MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD
title MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD
title_full MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD
title_fullStr MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD
title_full_unstemmed MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD
title_short MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD
title_sort microrna-302b enhances the sensitivity of hepatocellular carcinoma cell lines to 5-fu via targeting mcl-1 and dpyd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632720/
https://www.ncbi.nlm.nih.gov/pubmed/26457704
http://dx.doi.org/10.3390/ijms161023668
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