Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems

Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their...

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Autores principales: Jiang, Feng, Liu, Biao, Lu, Jun, Li, Fangfei, Li, Defang, Liang, Chao, Dang, Lei, Liu, Jin, He, Bing, Atik Badshah, Shaikh, Lu, Cheng, He, Xiaojuan, Guo, Baosheng, Zhang, Xiao-Bing, Tan, Weihong, Lu, Aiping, Zhang, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632726/
https://www.ncbi.nlm.nih.gov/pubmed/26473828
http://dx.doi.org/10.3390/ijms161023784
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author Jiang, Feng
Liu, Biao
Lu, Jun
Li, Fangfei
Li, Defang
Liang, Chao
Dang, Lei
Liu, Jin
He, Bing
Atik Badshah, Shaikh
Lu, Cheng
He, Xiaojuan
Guo, Baosheng
Zhang, Xiao-Bing
Tan, Weihong
Lu, Aiping
Zhang, Ge
author_facet Jiang, Feng
Liu, Biao
Lu, Jun
Li, Fangfei
Li, Defang
Liang, Chao
Dang, Lei
Liu, Jin
He, Bing
Atik Badshah, Shaikh
Lu, Cheng
He, Xiaojuan
Guo, Baosheng
Zhang, Xiao-Bing
Tan, Weihong
Lu, Aiping
Zhang, Ge
author_sort Jiang, Feng
collection PubMed
description Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.
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spelling pubmed-46327262015-11-23 Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems Jiang, Feng Liu, Biao Lu, Jun Li, Fangfei Li, Defang Liang, Chao Dang, Lei Liu, Jin He, Bing Atik Badshah, Shaikh Lu, Cheng He, Xiaojuan Guo, Baosheng Zhang, Xiao-Bing Tan, Weihong Lu, Aiping Zhang, Ge Int J Mol Sci Review Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems. MDPI 2015-10-09 /pmc/articles/PMC4632726/ /pubmed/26473828 http://dx.doi.org/10.3390/ijms161023784 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiang, Feng
Liu, Biao
Lu, Jun
Li, Fangfei
Li, Defang
Liang, Chao
Dang, Lei
Liu, Jin
He, Bing
Atik Badshah, Shaikh
Lu, Cheng
He, Xiaojuan
Guo, Baosheng
Zhang, Xiao-Bing
Tan, Weihong
Lu, Aiping
Zhang, Ge
Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
title Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
title_full Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
title_fullStr Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
title_full_unstemmed Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
title_short Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems
title_sort progress and challenges in developing aptamer-functionalized targeted drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632726/
https://www.ncbi.nlm.nih.gov/pubmed/26473828
http://dx.doi.org/10.3390/ijms161023784
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