Cargando…

p53 siRNA - a therapeutic tool with significant implication in the modulation of apoptosis and angiogenic pathways

BACKGROUND AND AIMS: siRNAs represent an encouraging novel alternative in cancer therapy as a result of targeting the mutated tumour suppressor genes or activated oncogenes. Targeting oncogenic signals, as the mutated p53 gene that gains oncogenic role, we observed inhibition of migration, a downreg...

Descripción completa

Detalles Bibliográficos
Autores principales:	BRAICU, OVIDIU, PILECZKI, VALENTINA, BRAICU, CORNELIA, ACHIMAS-CADARIU, PATRICIU, IRIMIE, ALEXANDRU, BERINDAN-NEAGOE, IOANA
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Iuliu Hatieganu University of Medicine and Pharmacy 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632892/ https://www.ncbi.nlm.nih.gov/pubmed/26609266 http://dx.doi.org/10.15386/cjmed-434

Ejemplares similares

Dual Targeted Therapy with p53 siRNA and Epigallocatechingallate in a Triple Negative Breast Cancer Cell Model
por: Braicu, Cornelia, et al.
Publicado: (2015)

Combining the chemotherapeutic effects of epigallocatechin 3-gallate with siRNA-mediated p53 knock-down results in synergic pro-apoptotic effects
por: Berindan-Neagoe, Ioana, et al.
Publicado: (2012)

miRNA expression profiling in formalin-fixed paraffin-embedded endometriosis and ovarian cancer samples
por: Braicu, Ovidiu-Leonard, et al.
Publicado: (2017)

Double gene siRNA knockdown of mutant p53 and TNF induces apoptosis in triple-negative breast cancer cells
por: Pileczki, Valentina, et al.
Publicado: (2016)

Aberrant miRNAs expressed in HER-2 negative breast cancers patient
por: Braicu, Cornelia, et al.
Publicado: (2018)

Normalization of gene expression measurement of tissue samples obtained by transurethral resection of bladder tumors
por: Pop, Laura A, et al.
Publicado: (2016)

Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
por: Achimas-Cadariu, Patriciu, et al.
Publicado: (2022)

TNF-α Gene Knockout in Triple Negative Breast Cancer Cell Line Induces Apoptosis
por: Pileczki, Valentina, et al.
Publicado: (2012)

Clinical and pathological implications of miRNA in bladder cancer
por: Braicu, Cornelia, et al.
Publicado: (2015)

The Relationships Between Biological Activities and Structure of Flavan-3-Ols
por: Braicu, Cornelia, et al.
Publicado: (2011)

Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
por: Irimie, Alexandra Iulia, et al.
Publicado: (2015)

Cancer-Associated Stemness and Epithelial-to-Mesenchymal Transition Signatures Related to Breast Invasive Carcinoma Prognostic
por: Groza, Iulia-Monica, et al.
Publicado: (2020)

Comprehensive Analysis of the Expression of Key Genes Related to Hippo Signaling and Their Prognosis Impact in Ovarian Cancer
por: Kubelac, Paul, et al.
Publicado: (2021)

Evaluation of cellular and molecular impact of zearalenone and Escherichia coli co-exposure on IPEC-1 cells using microarray technology
por: Braicu, Cornelia, et al.
Publicado: (2016)

The Function of Non-Coding RNAs in Lung Cancer Tumorigenesis
por: Braicu, Cornelia, et al.
Publicado: (2019)

Molecular Markers in the Pathogenesis of Cholangiocarcinoma: Potential for Early Detection and Selection of Appropriate Treatment
por: Braicu, Cornelia, et al.
Publicado: (2009)

Hepatocellular Carcinoma: Tumorigenesis and Prediction Markers
por: Braicu, Cornelia, et al.
Publicado: (2009)

Nanopharmacology in translational hematology and oncology
por: Tomuleasa, Ciprian, et al.
Publicado: (2014)

The added value of CA125, HE4, and CA72-4 as markers for ovarian endometriosis diagnosis
por: Micu, Romeo, et al.
Publicado: (2023)

Effect of Helix aspersa extract on TNFα, NF-κB and some tumor suppressor genes in breast cancer cell line Hs578T
por: El Ouar, Ibtissem, et al.
Publicado: (2017)

Gene Expression Patterns Unveil New Insights in Papillary Thyroid Cancer
por: Saftencu, Mihai, et al.
Publicado: (2019)

A Comprehensive Picture of Extracellular Vesicles and Their Contents. Molecular Transfer to Cancer Cells
por: Jurj, Ancuta, et al.
Publicado: (2020)

The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers
por: BOCHIS, OVIDIU VASILE, et al.
Publicado: (2015)

Ovarian endometriosis, a precursor of ovarian cancer: Histological aspects, gene expression and microRNA alterations (Review)
por: Gaia-Oltean, Adriana Ioana, et al.
Publicado: (2021)

Identification of Core Genes Involved in the Progression of Cervical Cancer Using an Integrative mRNA Analysis
por: Dudea-Simon, Marina, et al.
Publicado: (2020)

Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death
por: Chira, Sergiu, et al.
Publicado: (2018)

Early transcriptional pattern of angiogenesis induced by EGCG treatment in cervical tumour cells
por: Tudoran, Oana, et al.
Publicado: (2012)

The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?
por: Jurj, Ancuta, et al.
Publicado: (2022)

Investigating Circular RNAs Using qRT-PCR; Roundup of Optimization and Processing Steps
por: Drula, Rares, et al.
Publicado: (2023)

The Unforeseen Non-Coding RNAs in Head and Neck Cancer
por: Irimie, Alexandra Iulia, et al.
Publicado: (2018)

RNA interference: new mechanistic and biochemical insights with application in oral cancer therapy
por: Buduru, Smaranda, et al.
Publicado: (2018)

Progress in Research on the Role of Flavonoids in Lung Cancer
por: Zanoaga, Oana, et al.
Publicado: (2019)

Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention
por: Irimie, Alexandra Iulia, et al.
Publicado: (2019)

Predictors of limph node metastasis in endometrial cancer
por: IGNAT, FLORIN LAURENTIU, et al.
Publicado: (2013)

Decoding the Emerging Patterns Exhibited in Non-coding RNAs Characteristic of Lung Cancer with Regard to their Clinical Significance
por: Sonea, Laura, et al.
Publicado: (2018)

A Group of Tumor-Suppressive micro-RNAs Changes Expression Coordinately in Colon Cancer
por: Farc, Ovidiu, et al.
Publicado: (2023)

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
por: Irimie, Alexandra Iulia, et al.
Publicado: (2017)

Microarray based gene expression analysis of Sus Scrofa duodenum exposed to zearalenone: significance to human health
por: Braicu, Cornelia, et al.
Publicado: (2016)

The World of Oral Cancer and Its Risk Factors Viewed from the Aspect of MicroRNA Expression Patterns
por: Aghiorghiesei, Ovidiu, et al.
Publicado: (2022)

MicroRNAs as regulators of apoptosis mechanisms in cancer
por: PILECZKI, VALENTINA, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ul1f0duavat1qogt89qpl9d4q4