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Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System

Leptin receptor, which is encoded by the diabetes (db) gene and is highly expressed in the choroid plexus, regulatesenergy homeostasis, the balance between food intake and energy expenditure, fertility and bone mass. Here, using CRISPR/Cas9 technology, we created the leptin receptor knockout rat. Ho...

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Detalles Bibliográficos
Autores principales:	Bao, Dan, Ma, Yuanwu, Zhang, Xu, Guan, Feifei, Chen, Wei, Gao, Kai, Qin, Chuan, Zhang, Lianfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633582/ https://www.ncbi.nlm.nih.gov/pubmed/26537785 http://dx.doi.org/10.1038/srep15942

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