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A striking reduction of simple loudness adaptation in autism

Reports of sensory disturbance, such as loudness sensitivity or sound intolerance, are ubiquitous in Autism Spectrum Disorder (ASD) but a mechanistic explanation for these perceptual differences is lacking. Here we tested adaptation to loudness, a process that regulates incoming sensory input, in ad...

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Detalles Bibliográficos
Autores principales: Lawson, Rebecca P., Aylward, Jessica, White, Sarah, Rees, Geraint
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633623/
https://www.ncbi.nlm.nih.gov/pubmed/26537694
http://dx.doi.org/10.1038/srep16157
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author Lawson, Rebecca P.
Aylward, Jessica
White, Sarah
Rees, Geraint
author_facet Lawson, Rebecca P.
Aylward, Jessica
White, Sarah
Rees, Geraint
author_sort Lawson, Rebecca P.
collection PubMed
description Reports of sensory disturbance, such as loudness sensitivity or sound intolerance, are ubiquitous in Autism Spectrum Disorder (ASD) but a mechanistic explanation for these perceptual differences is lacking. Here we tested adaptation to loudness, a process that regulates incoming sensory input, in adults with ASD and matched controls. Simple loudness adaptation (SLA) is a fundamental adaptive process that reduces the subjective loudness of quiet steady-state sounds in the environment over time, whereas induced loudness adaptation (ILA) is a means of generating a reduction in the perceived volume of louder sounds. ASD participants showed a striking reduction in magnitude and rate of SLA relative to age and ability-matched typical adults, but in contrast ILA remained intact. Furthermore, rate of SLA predicted sensory sensitivity coping strategies in the ASD group. These results provide the first evidence that compromised neural mechanisms governing fundamental adaptive processes might account for sound sensitivity in ASD.
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spelling pubmed-46336232015-11-05 A striking reduction of simple loudness adaptation in autism Lawson, Rebecca P. Aylward, Jessica White, Sarah Rees, Geraint Sci Rep Article Reports of sensory disturbance, such as loudness sensitivity or sound intolerance, are ubiquitous in Autism Spectrum Disorder (ASD) but a mechanistic explanation for these perceptual differences is lacking. Here we tested adaptation to loudness, a process that regulates incoming sensory input, in adults with ASD and matched controls. Simple loudness adaptation (SLA) is a fundamental adaptive process that reduces the subjective loudness of quiet steady-state sounds in the environment over time, whereas induced loudness adaptation (ILA) is a means of generating a reduction in the perceived volume of louder sounds. ASD participants showed a striking reduction in magnitude and rate of SLA relative to age and ability-matched typical adults, but in contrast ILA remained intact. Furthermore, rate of SLA predicted sensory sensitivity coping strategies in the ASD group. These results provide the first evidence that compromised neural mechanisms governing fundamental adaptive processes might account for sound sensitivity in ASD. Nature Publishing Group 2015-11-05 /pmc/articles/PMC4633623/ /pubmed/26537694 http://dx.doi.org/10.1038/srep16157 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lawson, Rebecca P.
Aylward, Jessica
White, Sarah
Rees, Geraint
A striking reduction of simple loudness adaptation in autism
title A striking reduction of simple loudness adaptation in autism
title_full A striking reduction of simple loudness adaptation in autism
title_fullStr A striking reduction of simple loudness adaptation in autism
title_full_unstemmed A striking reduction of simple loudness adaptation in autism
title_short A striking reduction of simple loudness adaptation in autism
title_sort striking reduction of simple loudness adaptation in autism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633623/
https://www.ncbi.nlm.nih.gov/pubmed/26537694
http://dx.doi.org/10.1038/srep16157
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