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A striking reduction of simple loudness adaptation in autism
Reports of sensory disturbance, such as loudness sensitivity or sound intolerance, are ubiquitous in Autism Spectrum Disorder (ASD) but a mechanistic explanation for these perceptual differences is lacking. Here we tested adaptation to loudness, a process that regulates incoming sensory input, in ad...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633623/ https://www.ncbi.nlm.nih.gov/pubmed/26537694 http://dx.doi.org/10.1038/srep16157 |
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author | Lawson, Rebecca P. Aylward, Jessica White, Sarah Rees, Geraint |
author_facet | Lawson, Rebecca P. Aylward, Jessica White, Sarah Rees, Geraint |
author_sort | Lawson, Rebecca P. |
collection | PubMed |
description | Reports of sensory disturbance, such as loudness sensitivity or sound intolerance, are ubiquitous in Autism Spectrum Disorder (ASD) but a mechanistic explanation for these perceptual differences is lacking. Here we tested adaptation to loudness, a process that regulates incoming sensory input, in adults with ASD and matched controls. Simple loudness adaptation (SLA) is a fundamental adaptive process that reduces the subjective loudness of quiet steady-state sounds in the environment over time, whereas induced loudness adaptation (ILA) is a means of generating a reduction in the perceived volume of louder sounds. ASD participants showed a striking reduction in magnitude and rate of SLA relative to age and ability-matched typical adults, but in contrast ILA remained intact. Furthermore, rate of SLA predicted sensory sensitivity coping strategies in the ASD group. These results provide the first evidence that compromised neural mechanisms governing fundamental adaptive processes might account for sound sensitivity in ASD. |
format | Online Article Text |
id | pubmed-4633623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46336232015-11-05 A striking reduction of simple loudness adaptation in autism Lawson, Rebecca P. Aylward, Jessica White, Sarah Rees, Geraint Sci Rep Article Reports of sensory disturbance, such as loudness sensitivity or sound intolerance, are ubiquitous in Autism Spectrum Disorder (ASD) but a mechanistic explanation for these perceptual differences is lacking. Here we tested adaptation to loudness, a process that regulates incoming sensory input, in adults with ASD and matched controls. Simple loudness adaptation (SLA) is a fundamental adaptive process that reduces the subjective loudness of quiet steady-state sounds in the environment over time, whereas induced loudness adaptation (ILA) is a means of generating a reduction in the perceived volume of louder sounds. ASD participants showed a striking reduction in magnitude and rate of SLA relative to age and ability-matched typical adults, but in contrast ILA remained intact. Furthermore, rate of SLA predicted sensory sensitivity coping strategies in the ASD group. These results provide the first evidence that compromised neural mechanisms governing fundamental adaptive processes might account for sound sensitivity in ASD. Nature Publishing Group 2015-11-05 /pmc/articles/PMC4633623/ /pubmed/26537694 http://dx.doi.org/10.1038/srep16157 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lawson, Rebecca P. Aylward, Jessica White, Sarah Rees, Geraint A striking reduction of simple loudness adaptation in autism |
title | A striking reduction of simple loudness adaptation in autism |
title_full | A striking reduction of simple loudness adaptation in autism |
title_fullStr | A striking reduction of simple loudness adaptation in autism |
title_full_unstemmed | A striking reduction of simple loudness adaptation in autism |
title_short | A striking reduction of simple loudness adaptation in autism |
title_sort | striking reduction of simple loudness adaptation in autism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633623/ https://www.ncbi.nlm.nih.gov/pubmed/26537694 http://dx.doi.org/10.1038/srep16157 |
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