Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects

Short-hairpin RNAs (shRNAs) are widely used to produce small-interfering RNAs (siRNAs) for gene silencing. Here we design an alternative siRNA precursor, named single-stranded, Argonaute 2 (Ago2)-processed interfering RNA (saiRNA), containing a 16–18 bp stem and a loop complementary to the target tr...

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Detalles Bibliográficos
Autores principales: Shang, Renfu, Zhang, Fengjuan, Xu, Beiying, Xi, Hairui, Zhang, Xue, Wang, Weihua, Wu, Ligang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633630/
https://www.ncbi.nlm.nih.gov/pubmed/26455506
http://dx.doi.org/10.1038/ncomms9430

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