Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis

Bone marrow stroma can protect acute myeloid leukemia (AML) cells against chemotherapeutic agents and provide anti-apoptosis and chemoresistance signals through secreting chemokine CXCL12 to activate its receptor CXCR4 on AML cells, resulting in minimal residual leukemia and relapse. Therefore disru...

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Detalles Bibliográficos
Autores principales: Li, Xiaojin, Guo, Hua, Duan, Hongyang, Yang, Yanlian, Meng, Jie, Liu, Jian, Wang, Chen, Xu, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633653/
https://www.ncbi.nlm.nih.gov/pubmed/26538086
http://dx.doi.org/10.1038/srep16228

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