FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae—Erg26p, Homo sapi...

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Detalles Bibliográficos
Autores principales: Helliwell, Stephen B., Karkare, Shantanu, Bergdoll, Marc, Rahier, Alain, Leighton-Davis, Juliet R., Fioretto, Celine, Aust, Thomas, Filipuzzi, Ireos, Frederiksen, Mathias, Gounarides, John, Hoepfner, Dominic, Hofmann, Andreas, Imbert, Pierre-Eloi, Jeker, Rolf, Knochenmuss, Richard, Krastel, Philipp, Margerit, Anais, Memmert, Klaus, Miault, Charlotte V., Rao Movva, N., Muller, Alban, Naegeli, Hans-Ulrich, Oberer, Lukas, Prindle, Vivian, Riedl, Ralph, Schuierer, Sven, Sexton, Jessica A., Tao, Jianshi, Wagner, Trixie, Yin, Hong, Zhang, Juan, Roggo, Silvio, Reinker, Stefan, Parker, Christian N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633953/
https://www.ncbi.nlm.nih.gov/pubmed/26456460
http://dx.doi.org/10.1038/ncomms9613

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