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MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas

Ovarian cancer is a silent disease with a poor prognosis that urgently requires new therapeutic strategies. In low-grade ovarian tumours, mutations in the MAP3K BRAF gene constitutively activate the downstream kinase MEK. Here we demonstrate that an additional MAP3K, MAP3K8 (TPL-2/COT), accumulates...

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Detalles Bibliográficos
Autores principales:	Gruosso, Tina, Garnier, Camille, Abelanet, Sophie, Kieffer, Yann, Lemesre, Vincent, Bellanger, Dorine, Bieche, Ivan, Marangoni, Elisabetta, Sastre-Garau, Xavier, Mieulet, Virginie, Mechta-Grigoriou, Fatima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633961/ https://www.ncbi.nlm.nih.gov/pubmed/26456302 http://dx.doi.org/10.1038/ncomms9583

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