Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production

Secondary antibody responses are marked by faster kinetics, improved antibody affinity and a switch from IgM to other immunoglobulin isotypes, most notably IgG, compared with primary responses. These changes protect from reinfection and represent the principle of most vaccination strategies. Yet, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Lutz, Johannes, Dittmann, Kai, Bösl, Michael R, Winkler, Thomas H, Wienands, Jürgen, Engels, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633962/
https://www.ncbi.nlm.nih.gov/pubmed/26815242
http://dx.doi.org/10.1038/ncomms9575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633962/
https://www.ncbi.nlm.nih.gov/pubmed/26815242
http://dx.doi.org/10.1038/ncomms9575

Ejemplares similares