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A virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A provides protection against viral challenge without priming for enhanced disease in cotton rats

BACKGROUND: Non‐replicating respiratory syncytial virus (RSV) vaccine candidates could potentially prime for enhanced respiratory disease (ERD) due to a T‐cell‐mediated immunopathology, following RSV infection. Vaccines with built‐in immune response modifiers, such as Toll‐like receptor (TLR) ligand...

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Detalles Bibliográficos
Autores principales:	Kamphuis, Tobias, Stegmann, Toon, Meijerhof, Tjarko, Wilschut, Jan, de Haan, Aalzen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2013
Materias:	Part 3
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634254/ https://www.ncbi.nlm.nih.gov/pubmed/23575113 http://dx.doi.org/10.1111/irv.12112

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