Bat cells from Pteropus alecto are susceptible to influenza A virus infection and reassortment

Waterfowl are primary hosts for influenza A viruses (IAVs); however, there is sporadic infection of swine and other species that pose a risk of zoonotic spread. Yellow‐shouldered bats were shown to be hosts of an IAV, thereby constituting a potential novel reservoir. We show that Pteropus alecto kid...

Descripción completa

Detalles Bibliográficos
Autores principales: Dlugolenski, Daniel, Jones, Les, Tompkins, S. Mark, Crameri, Gary, Wang, Lin‐Fa, Tripp, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2013
Materias:
Part 1
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634287/
https://www.ncbi.nlm.nih.gov/pubmed/23710888
http://dx.doi.org/10.1111/irv.12128
Descripción
Sumario:Waterfowl are primary hosts for influenza A viruses (IAVs); however, there is sporadic infection of swine and other species that pose a risk of zoonotic spread. Yellow‐shouldered bats were shown to be hosts of an IAV, thereby constituting a potential novel reservoir. We show that Pteropus alecto kidney cells (PaKi) are susceptible to infection and sustain replication of A/WSN/33 (H1N1) and A/Vietnam/1203/04 (H5N1). Importantly, we show that co‐infection of PaKi cells results in novel reassortants.

Ejemplares similares